An interconnected network of neurons and synapses

Autism spectrum disorder · children aged 4–18 · all levels, non-verbal included

Supporting your child's communication

If your child finds language, social contact or everyday change hard, our programme works to ease those barriers. It targets the immune and neurological factors linked to autism, with the goal of supporting your child's communication, sensory regulation and daily functioning. We do not try to change who your child is. Every plan is built for one child, around their age, level and developmental profile.

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A single neuron with a dense dendritic tree

What autism is, in plain terms.

Autism is a neurodevelopmental condition. It shapes how a child communicates, reads social cues, processes what their senses take in and copes with change. It is called a spectrum because the picture differs so much from one child to the next. Behind that picture, research has found biological factors, such as immune dysregulation, ongoing neuroinflammation and, in some children, metabolic strain, that can add to how heavily symptoms weigh on a child. These factors sit apart from the underlying genetics, and they can be worked on. Our programme does not alter genetics and makes no claim to cure autism. It works on those biological barriers, so more of a child's own development has room to come through.

Level 1 speaks, but conversation and change are hard
Level 2 limited speech, needs substantial support
Level 3 minimal or non-verbal, very substantial support
Co-occurring often with ADHD, anxiety, sleep or GI issues

What the programme works to support.

We do not promise a cure, and we never treat autism as something to be erased. What we work for is to ease the barriers your child meets each day — supporting the areas autism most often makes harder, so more of daily life becomes theirs to take part in.

Communication & language Words, phrases, and both understanding and being understood.
Social engagement Eye contact, shared attention and connecting with people.
Motor skills & coordination Fine and gross motor control, steadiness and everyday tasks.
Sensory regulation Easing sensory overload, so sounds, touch and light feel less overwhelming.
Sleep & daily routine Steadier sleep, smoother transitions and calmer daily routines.

What families of our ASD patients report.

A registry of what parents have reported since 2019, measured at follow-up and shown as it is. Across the 108 children with autism we have supported, improvement in at least one area is common. Outcomes vary a great deal from child to child, though, and this evidence should be read with care — it is observational, not trial data, and an average is never a promise.

Share of children whose families reported a meaningful improvement · 108 children, since 2019

Communication and language79%
Social engagement and connection80%
Behavioural and emotional regulation81%
Sensory regulation and attention77%
Sleep and daily routines82%
Overall developmental progress83%

3.5 years

Average follow-up over which developmental gains were sustained across our ASD patients.

Every child is different — outcomes depend on your child's level, their age when treatment begins, their developmental profile and their own biological response.

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How the programme works for autism.

No two protocols are the same. A medical board builds your child's plan from up to five biological components — combined, sequenced and dosed for their age, level and developmental profile. Each works on a different biological factor linked to autism. Together they aim to ease immune dysregulation, calm neuroinflammation and support the connectivity the developing brain relies on, so communication, regulation and daily functioning have more room to grow.

Non-surgical — delivered by gentle intranasal exosomes and minimally invasive administration, with no general anaesthesia
Adapted for children, including sensory-sensitive and non-verbal children across the whole spectrum
Runs alongside ABA, speech and occupational therapy, which continue without interruption
Works on the biology that may amplify symptoms, without suppressing the immune system or changing who your child is

The developing brain is sensitive to inflammatory stress. In children whose immune markers point to imbalance or chronic activation, T-regulatory cells are the immune system's own way of turning down that overactivity — restoring regulation so inflammation does not interfere with neural development, communication pathways and sensory processing. They calm the excess without weakening your child's normal immune defence. Prepared from your child's own blood by a low-volume collection under paediatric supervision, or from a certified donor where that is more appropriate. This is the component we often lead with.
Many children on the spectrum show raised inflammatory markers and immune dysregulation that research links to a heavier symptom burden. Mesenchymal stem cells are multipotent regenerative cells that modulate that overactive inflammatory response rather than switch the immune system off, easing the chronic neuroinflammation that can place biological stress on the developing nervous system. They carry almost no rejection markers, so they can be used without immunosuppression, whether taken from your child's own bone marrow by a small-volume sample under paediatric supervision or from a matched donor.
Nanoscale vesicles from regenerative cells, carrying neuroprotective factors and regulatory signals, given intranasally. The child simply breathes the formulation in through the nose, and the exosomes cross straight into the central nervous system by the olfactory route, quieting neuroinflammatory signalling in regions that are hard to reach. For sensory-sensitive children, this removes one of the biggest barriers to treatment: there are no needles and no infusion lines, so the delivery itself causes no distress.
Gentle, low-intensity microcurrent, calibrated for children. This is not about forcing neural pathways to behave differently. It supports the brain's own regulatory mechanisms through targeted microcirculation and cellular metabolism, which can translate into steadier sensory processing, better focus and calmer emotional regulation. Sessions are always set to your child's comfort and sensory tolerance, and many children accept them without any discomfort or overstimulation. No implant, no surgery and no anaesthesia.
Disturbed sleep, difficulty holding attention and low endurance are among the challenges parents describe most often, and in a subset of children they track with metabolic strain and mitochondrial dysfunction. Bioactive peptides, chosen for your child's metabolic profile and dosed for paediatric use, support the cellular energy production the brain draws on to regulate sleep, sustain attention and manage the sensory demands of an ordinary day.

Discuss your child's case

What to expect, step by step.

It begins with a conversation, and no obligation. Here is how the programme takes shape for your child.

Free medical review

A physician reviews your child's diagnosis, level, developmental history, current therapies and biological markers, remotely. No cost, no obligation.

Eligibility & plan

The medical board studies the documents and tells you honestly whether we can help — then designs a bespoke programme for your child, never a standard protocol.

Laboratory preparation

Cells are collected, prepared and quality-tested in our own laboratory, with full traceability. About 2–3 weeks.

Treatment in Budapest

Intranasal exosomes with minimally invasive cell administration — no surgery, no general anaesthesia, and every step paced for your child's comfort. We arrange your flights, transfers and accommodation.

Paediatric rehabilitation

Play-based sessions with a paediatric specialist — sensory integration, motor coordination and adaptive skills, adapted to your child's developmental level.

Long-term follow-up

A dedicated coordinator tracks behaviour, sleep, regulation and developmental milestones, with the family included throughout and ongoing access for reassessment.

Safety, and an honest word on expectations.

Safety comes first in every part of the programme. Each step is adapted to your child's age, weight, sensory sensitivity and clinical profile, and it is designed to be well-tolerated by children across the spectrum, including those with strong sensory sensitivities, anxiety and co-occurring conditions. The minimum age is 4; any request below that is assessed individually. Mild, short-lived reactions can happen and usually pass within a day or two. Before every session a paediatric physician confirms eligibility on site, and we adjust or postpone if anything has changed. We will only take your child's case when we believe we can realistically help.

Assessed individually before we proceed

Active infection or fever
Active cancer, or ongoing chemo- or radiotherapy
Severe heart or kidney failure
Pregnancy

These are standard contraindications. One alone does not automatically rule you out — each is weighed against your full clinical picture.

A patient receiving regenerative therapy in a calm treatment room, a clinician attending

The work continues after Budapest.

Autism affects the whole family, not only the child, and the months after treatment matter as much as the treatment itself. A paediatric rehabilitation specialist tracks regulation, communication and developmental milestones, parents receive structured guidance for supporting gains at home, and a coordinator stays in regular contact as your child's needs change.

A patient and a member of the medical team in conversation at the institute

From the families of our ASD patients.

At six our son had maybe ten words, most of them unclear. A few months after the programme he began putting words together into short phrases. His speech therapist said it was more progress than she had seen in the whole previous year. He is communicating now, and that is what matters to us.

Patient's father · Autism, Level 2 · France

She looks at us when we talk to her now. She lets us hug her. She tried a new food at dinner without a meltdown. Three months on, our daughter is calmer and more present, and her occupational therapist at home confirmed the sensory sensitivity had eased noticeably.

Patient's mother · Autism, Level 3 · Spain

Our son is five. He could not hold a crayon or stack blocks. After treatment his motor control improved visibly — he draws now and stands more steadily. His paediatrician in Rome told us the developmental gain was worth about eight months of typical progress.

Patient's mother · ASD with motor involvement · Italy

Our son is seven and non-verbal, and we came with low expectations. Within weeks he began pointing at things he wanted, then making sounds on purpose. His sleep went from waking five or six times a night to once or twice, and the school says he is calmer and more engaged. For a non-verbal child these are enormous changes.

Patient's father · Autism, Level 3, non-verbal · Saudi Arabia

By eight our daughter had plateaued. The ABA, speech and OT therapists were wonderful but said they had reached the ceiling. After the programme that ceiling moved. She follows two-step instructions now, and she sat through a whole family dinner without leaving the table. Her ABA therapist said the therapy finally works the way it should.

Patient's mother · Autism, Level 2 · United Kingdom

We were honest with ourselves that autism does not simply go away, and the team were honest with us about what was realistic. A year on, our daughter handles changes to her routine far better, her language keeps growing, and she started going to a small group class near Bologna. She seems more at ease in her own skin.

Patient's parents · Autism, Level 1 · Italy

Every child is different. Request a review to talk through your child's case with our medical team.

Request a medical review for your child.

Send us your child's diagnosis and we will review it. A medical advisor will be in touch — and will stay with you through the whole programme as your direct line to the medical team. Free, and no obligation.

By submitting this form, you consent to Caplan processing your personal data for the purpose of medical consultation in accordance with applicable data protection regulations.

The evidence we build on.

Our approach draws on published, peer-reviewed research into cell and regenerative therapy for autism spectrum disorder. A selection of the studies that inform it:

These studies inform our protocol. They report findings from research populations, and every child responds differently. We assess what they mean for your child's case individually.